Through the research theme, “Proteome Dynamics in Health, Disease and Treatment”, the BCPN pursues collaborative research projects that address critical health issues. By leveraging the established proteomics infrastructure and expertise in the province, the BCPN is able to function as an integrated proteomics research platform with tasks distributed according to laboratory expertise. The BCPN provides assistance with grant applications for large-scale collaborative proteomics projects. In addition, the BCPN holds an annual competition for seed funding for pilot projects - Small Projects Health Research Grants.
BCPN Collaborative Research Projects
The BCPN has launched two collaborative research projects within the local research community.
Integrated Proteomics of Disease Genomes
A genomic study has described the mutations occurring in the development and progression of a lobular metastatic breast cancer tumor. Sequencing of the pleural effusion RNA and DNA revealed 32 somatic coding mutations, 19 of which were not present in the primary tumor. Proteomics methodologies are being used to investigate whether the expression of mutant proteins induce functional changes in pleural effusion cells.
Chromosome 6 Human Proteome Project
A global chromosome-centric Human Proteome Project was officially launched at the HUPO 2010 meeting. This initiative will identify, quantify and characterize the complete human proteome which contains over 20,000 protein coding genes. A group of BC-led collaborative researchers will lay the groundwork for the Canadian contribution towards the Human Proteome Project. The pilot project will focus on the identification and quantitation of proteins coded by chromosome 6.
Please contact info(at)bcpn.ca if you wish to discuss opportunities for collaboration.
The purpose of the SPHRG program is to encourage university or hospital based research groups in British Columbia to develop innovative research programs that use proteomics as a tool for biological research in human health. Individual grants are limited to $20,000.